DSP medlemmer har nu mulighed for at deltage i Dansk Parodontologisk Selskab (DPS) møder

Bestyrelsen har fornøjelsen af at informere foreningens medlemmer om, at det nu i kraft af et øget samarbejde mellem de to danske parodontologiske selskaber er muligt, som medlem af Dansk Selskab for Parodontologi at tilmelde sig Dansk Parodontologisk Selskabs forårsmåde til medlemspris. Emnet er endo-parodontale læsioner med professor Henrik Dommisch fra Charité Universitätsmedizin, Berlin. Mødet afholdes både i København og i Aarhus hhv. den 8. og 9. marts..

Tilmelding skal ske via Dansk Parodontologisk Selskabs kasserer Uwe V. Henriksen på kasserer@periodont.dk.

Med venlig hilsen,

Bestyrelsen i DSP

Nyt studie om effekten af parodontalbehandling på blodsukkerniveau hos patienter med type 2 diabetes

Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial.

D’Aiuto F1Gkranias N2Bhowruth D3Khan T3Orlandi M4Suvan J4Masi S3Tsakos G5Hurel S6Hingorani AD3Donos N2Deanfield JE3TASTE Group.


Chronic inflammation is believed to be a major mechanism underlying the pathophysiology of type 2 diabetes. Periodontitisis a cause of systemic inflammation. We aimed to assess the effects of periodontal treatment on glycaemic control in people with type 2 diabetes.


In this 12 month, single-centre, parallel-group, investigator-masked, randomised trial, we recruited patients with type 2 diabetes, moderate-to-severe periodontitis, and at least 15 teeth from four local hospitals and 15 medical or dental practices in the UK. We randomly assigned patients (1:1) using a computer-generated table to receive intensive periodontal treatment (IPT; whole mouth subgingival scaling, surgical periodontal therapy [if the participants showed good oral hygiene practice; otherwise dental cleaning again], and supportive periodontal therapy every 3 months until completion of the study) or control periodontal treatment (CPT; supra-gingival scaling and polishing at the same timepoints as in the IPT group). Treatment allocation included a process of minimisation in terms of diabetes onset, smoking status, sex, and periodontitis severity. Allocation to treatment was concealed in an opaque envelope and revealed to the clinician on the day of first treatment. With the exception of dental staff who performed the treatment and clinical examinations, all study investigators were masked to group allocation. The primary outcome was between-group difference in HbA1c at 12 months in the intention-to-treat population. This study is registered with the ISRCTN registry, number ISRCTN83229304.


Between Oct 1, 2008, and Oct 31, 2012, we randomly assigned 264 patients to IPT (n=133) or CPT (n=131), all of whom were included in the intention-to-treat population. At baseline, mean HbA1c was 8·1% (SD 1·7) in both groups. After 12 months, unadjusted mean HbA1c was 8·3% (SE 0·2) in the CPT group and 7·8% (0·2) in the IPT group; with adjustment for baseline HbA1c, age, sex, ethnicity, smoking status, duration of diabetes, and BMI, HbA1c was 0·6% (95% CI 0·3-0·9; p<0·0001) lower in the IPT group than in the CPT group. At least one adverse event was reported in 30 (23%) of 133 patients in the IPT group and 23 (18%) of 131 patients in the CPT group. Serious adverse events were reported in 11 (8%) patients in the IPT group, including one (1%) death, and 11 (8%) patients in the CPT group, including three (2%) deaths.


Compared with CPT, IPT reduced HbA1c in patients with type 2 diabetes and moderate-to-severe periodontitis after 12 months. These results suggest that routine oral health assessment and treatment of periodontitis could be important for effective management of type 2 diabetes.

Kilde: Pubmed.com

Link til studiet: https://www.ncbi.nlm.nih.gov/pubmed/30472992

Danske politikere ignorerer, at det kan betale sig at have sunde tænder – kronik af Palle Holmstrup den 25.11.2018 i Berlingske

Kære DSP-medlemmer,

Søndag den 25.11.2018 var DSP formand, Palle Holmstrup,Berlingske Tidende 25. november 2018 – Palle Holmstrup forfatter til en kronik i Berlingske vedrørende brugerbetaling ved tandbehandling.

Kronikken er vedhæftet – god læselyst.

Med venlig hilsen,

Bestyrelsen i DSP

Nyeste udgave af Aktuel Nordisk Odontologi

Kære medlemmer,

Den nyeste udgave af Aktuel Nordisk Odontologi er nu tilgængelig til en fordelagtig pris.

Bogen kan bestilles via nedenstående link:


med venlig hilsen,

Bestyrelsen i DSP

Impact of Periodontitis Case Criteria: A Cross-Sectional Study of Lifestyle

Kongstad J1Enevold C2Christensen LB1Fiehn NE3Holmstrup P1.

J Periodontol. 2017 Jun;88(6):602-609. doi: 10.1902/jop.2017.160426. Epub 2017 Jan 27.


Associations of risk factors/indicators with periodontitis may depend on the included case criterion. The objective of the current study is to evaluate differences in outcome by applying five periodontitis case definitions for cross-sectional associations with lifestyle factors among participants of the Danish Health Examination Survey (DANHES).


A total of 4,402 adults aged 18 to 96 years from the general health examination of DANHES had a periodontal examination consisting of half-mouth registration at six sites per tooth including probing depth (PD) and clinical attachment level (CAL). Periodontitis was defined according to severe periodontitis, European Workshop of Periodontology (EWP)-specific, meanCAL ≥2.55 mm, CAL-tertile, and PD-CAL definitions. Multivariable logistic regression models fitted the association of age, sex, smoking status, diabetes mellitus, educational level, alcohol consumption, body mass index, physical activity, body fat percentage, waist circumference, triglycerides, total cholesterol, and C-reactive protein with periodontitis.


Number of cases captured by the five periodontitis case definitions ranged from 337 (9.2%) to 1,136 (31.0%). A total of 224 participants were defined as periodontitis cases by all five criteria. Analyses on 3,665 participants with complete data revealed statistically significant associations of age and smoking with all periodontitis case definitions and of male sex with severe periodontitis and EWP-specific definitions. Educational level (two lowest groups) was related to three periodontitis criteria. Among obesity and hyperlipidemia measures no factors were related to periodontitis.


Regression analyses showed little difference in odds ratio across the five periodontitis case definitions; however, the level of significance did show some variation.


Kilde: PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28128681

Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

Belstrøm D#1Constancias F#2Liu Y2Yang L2Drautz-Moses DI2Schuster SC2Kohli GS2Jakobsen TH3Holmstrup P1Givskov M2,3.

NPJ Biofilms Microbiomes. 2017 Oct 2;3:23. doi: 10.1038/s41522-017-0031-4. eCollection 2017

The taxonomic composition of the salivary microbiota has been reported to differentiate between oral health and disease. However, information on bacterial activity and gene expression of the salivary microbiota is limited. The purpose of this study was to perform metagenomic and metatranscriptomic characterization of the salivary microbiota and test the hypothesis that salivary microbial presence and activity could be an indicator of the oral health status.

Stimulated saliva samples were collected from 30 individuals (periodontitis: n = 10, dental caries: n = 10, oral health: n = 10). Salivary microbiota was characterized using metagenomics and metatranscriptomics in order to compare community composition and the gene expression between the three groups.

Streptococcus was the predominant bacterial genus constituting approx. 25 and 50% of all DNA and RNA reads, respectively. A significant disease-associated higher relative abundance of traditional periodontal pathogens such as Porphyromonas gingivalis and Filifactor alocis and salivary microbial activity of Falocis was associated with periodontitis. Significantly higher relative abundance of caries-associated bacteria such as Streptococcus mutans and Lactobacillus fermentum was identified in saliva from patients with dental caries. Multiple genes involved in carbohydrate metabolism were significantly more expressed in healthy controls compared to periodontitis patients.

Using metagenomics and metatranscriptomics we show that relative abundance of specific oral bacterial species and bacterial gene expression in saliva associates with periodontitis and dental caries. Further longitudinal studies are warranted to evaluate if screening of salivary microbial activity of specific oral bacterial species and metabolic gene expression can identify periodontitis and dental caries at preclinical stages.

Kilde: PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28979798

Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis.

Damgaard C1,2Reinholdt J3Enevold C2Fiehn NE4Nielsen CH2Holmstrup P1

J Oral Microbiol. 2017 Sep 10;9(1):1374154. doi: 10.1080/20002297.2017.1374154. eCollection 2017.

Objectives: The aim was to elucidate whether levels of circulating antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD).

Design: Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of A. actinomycetemcomitans and P. gingivalis were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria.

Results: Levels of antibodies against P. gingivalis (OR = 1.48) and A. actinomycetemcomitans (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level of education using multivariable logistic regression analysis, only increasing body mass index (BMI; 1.09), previous smoking (1.99), and increasing age (decades) (2.27) remained associated with CVD. Increased levels of antibodies against P. gingivalis (1.34) remained associated with periodontitis after adjusting for other risk factors.

Conclusions: CVD and periodontitis were associated with levels of IgG antibodies to P. gingivalis or A. actinomycetemcomitans in univariable analyses, but only the association of P. gingivalis antibody levels with periodontitis reached statistical significance after adjustment for common confounders. Age, in particular, influenced this relationship.

Kilde: Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29081914

Salivary cytokine levels in early gingival inflammation

Belstrøm D1Damgaard C1,2Könönen E3Gürsoy M3Holmstrup P1Gürsoy UK3.

J Oral Microbiol. 2017 Aug 11;9(1):1364101. doi: 10.1080/20002297.2017.1364101. eCollection 2017.


Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine levels in early gingival inflammation. The aim of this study was to determine salivary levels of vascular endothelial growth factor (VEGF), interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, IL-1β, and IL-1 receptor antagonist (IL-1Ra) in gingival inflammation. Twenty-eight systemically and orally healthy nonsmokers abstained from oral hygiene protocols for 10 days. After that, self-performed cleaning was resumed for 14 days. Plaque and gingival indexes were measured, and saliva samples were collected at days 1, 4, 7, 10, and 24. Salivary cytokines were detected with Luminex®-xMAP™. Salivary IL-1β, IL-1Ra, and VEGF levels decreased after 10 days’ development of experimental gingivitis and reached baseline levels at the end of the 2-week resolution period. Salivary IL-8 levels decreased and remained low during development and resolution of experimental gingivitis. Initial inflammation in gingival tissues is associated with a decrease in inflammatory cytokines in saliva. Further studies are needed to evaluate if inflammatory cytokines bind to their functional receptors within the gingival tissue during early gingivitis, which may limits their spillover to the gingival crevice and ultimately saliva.


Gingivitis; human; interleukin-1 receptor antagonist; interleukin-1β; interleukin-8; monocyte chemoattractant protein-1; vascular endothelial growth factor


Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

Holmstrup P1Damgaard C1,2Olsen I3Klinge B4,5Flyvbjerg A6Nielsen CH1,2Hansen PR1,7.

J Oral Microbiol. 2017 Jun 14;9(1):1332710. doi: 10.1080/20002297.2017.1332710. eCollection 2017.


Increasing evidence has suggested an independent association between periodontitis and a range of comorbidities, for example cardiovascular disease, type 2 diabetes, rheumatoid arthritis, osteoporosis, Parkinson’s disease, Alzheimer’s disease, psoriasis, and respiratory infections. Shared inflammatory pathways are likely to contribute to this association, but distinct causal mechanisms remain to be defined. Some of these comorbid conditions may improve by periodontal treatment, and a bidirectional relationship may exist, where, for example, treatment of diabetes can improve periodontal status. The present article presents an overview of the evidence linking periodontitis with selected systemic diseases and calls for increased cooperation between dentists and medical doctors to provide optimal screening, treatment, and prevention of both periodontitis and its comorbidities.


Alzheimer’s disease; Parkinson’s disease; Periodontitis; cardiovascular disease; comorbidity; low-grade inflammation; osteoporosis; periodontal disease; pneumonia; psoriasis; rheumatoid arthritis; type 2 diabetes