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Stem cells in bone regeneration, a systematic approach and pilot study in humans
Sted: Gentofte Hotel
Dato: 18. maj 2017
Tid: 17:30 - 19:30

ScSP 2017 CONGRESS PERIODONTAL TREATMENT AND MAINTENANCE: DO WE NEED TO MEDICATE TO REGENERATE?
Sted: Alandica Culture & Congress Centre
Dato: 24. august 2017 - 27. august 2017
Tid: Hele dagen

Dansk Selskab til Studiet af Parodontologi blev stiftet 23. januar 1953, som den første parodontologiske forening i Danmark.


Formålet med foreningen er at styrke kendskabet til sygdomsudvikling og behandling af marginal parodontitis samt peri-implantitis.
Foreningen har tandlæger som medlemmer og tandplejere som associerede medlemmer, hovedsageligt fra Danmark. Foreningen har i dag små 200 aktive medlemmer.

Foreningen afholder årligt 4 foredrag samt en generalforsamling. Inden hvert foredrag er der en sammenkomst med et lille traktement. Ved generalforsamling, som afholdes i marts/april, er der en middag.

Presence and consequence of tooth periapical radiolucency in patients with cirrhosis.

Hepat Med. 2016 Sep 13;8:97-103. eCollection 2016.

Abstract

BACKGROUND:

Periapical radiolucency is the radiographic sign of inflammatory bone lesions around the apex of the tooth. We determined the prevalence and predictors of periapical radiolucency in patients with cirrhosis and the association with systemic inflammation status and cirrhosis-related complications.

METHODS:

A total of 110 cirrhosis patients were consecutively enrolled. Periapical radiolucency was defined as the presence of radiolucency or widening of the periapical periodontal ligament space to more than twice the normal width. Predictors of periapical radiolucency and the association with systemic inflammation markers and cirrhosis-related complications were explored by univariable and multivariable logistic regression analyses.

RESULTS:

Periapical radiolucency was present in one or more teeth in 46% of the patients. Strong predictors were gross caries (odds ratio [OR] 3.12, 95% confidence interval [CI] 1.43-6.79) and severe periodontitis (OR 3.98, 95% CI 1.04-15.20). Also old age (OR 1.10, 95% CI 1.01-1.19) and smoking (OR 3.24, 95% CI 1.02-17.62) were predictors. However, cirrhosis etiology (alcoholic vs nonalcoholic) or severity (Model of End-Stage Liver Disease score) were not predictors. The patients with periapical radiolucency had higher C-reactive protein (15.8 mg/L vs 8.1 mg/L, P=0.02) and lower albumin contents (25 g/L vs 28 g/L, P=0.04) than those without. Furthermore, the patients with periapical radiolucency had a higher prevalence of cirrhosis-related complications such as ascites, hepatic encephalopathy, and/or variceal bleeding (46% vs 27%, P=0.05).

CONCLUSION:

Periapical radiolucency is often present as an element of poor oral health status and likely has an adverse clinical significance, which should motivate diagnostic and clinical attention to the findings.

https://www.ncbi.nlm.nih.gov/pubmed/27695370

Kilde: Pubmed.com

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Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction.

PLoS One. 2016 Dec 28;11(12):e0168771. doi: 10.1371/journal.pone.0168771. eCollection 2016.

Abstract

Chronic infection is associated with an increased risk of atherothrombotic disease and direct bacterial infection of arteries has been suggested to contribute to the development of unstable atherosclerotic plaques. In this study, we examined coronary thrombi obtained in vivo from patients with ST-segment elevation myocardial infarction (STEMI) for the presence of bacterial DNA and bacteria. Aspirated coronary thrombi from 22 patients with STEMI were collected during primary percutaneous coronary intervention and arterial blood control samples were drawn from radial or femoral artery sheaths. Analyses were performed using 16S polymerase chain reaction and with next-generation sequencing to determine bacterial taxonomic classification. In selected thrombi with the highest relative abundance of Pseudomonas aeruginosa DNA, peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) with universal and species specific probes was performed to visualize bacteria within thrombi. From the taxonomic analysis we identified a total of 55 different bacterial species. DNA from Pseudomonas aeruginosa represented the only species that was significantly associated with either thrombi or blood and was >30 times more abundant in thrombi than in arterial blood (p<0.0001). Whole and intact bacteria present as biofilm microcolonies were detected in selected thrombi using universal and P. aeruginosa-specific PNA-FISH probes. P. aeruginosa and vascular biofilm infection in culprit lesions may play a role in STEMI, but causal relationships remain to be determined.

https://www.ncbi.nlm.nih.gov/pubmed/28030624

Kilde: Pubmed.com

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